Insantatarium

Walkthrough:
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Pick up the large shard of glass by Santa's feet, then click his
knees followed by his belly and then his mouth. Santa will use 
the glass to cut the ropes he's tied in and stand up. Click the
cigarette to walk over and pick it up, next, click the lighter on
top of the wall drain. Santa will light the cigarette, click on the
laser contraption to blow smoke over the lasers to make them visible.

Click to grab the key ONLY when the lasers are in an open pattern 
(meaning a hole in the grid to fit your hand through), it will switch
through 3 patterns (NOTE: You have exactly 6 chances to get the timing
right, last time will result in a missing hand).

If successful, you will now have a key and the lock will be highlighted 
by a glowing wreath. Click on the lock and the room will fill with water.
The key to survival here (if you don't understand the puzzle right away) 
is to simply keep your air meter from depleting completely, you can do 
so by clicking the pipe on the left with the constant air flow (you'll 
see bubbles). The puzzle is actually simple, the light in under the chair
will glow 1 of 3 random colors, you must mix the correct colors by 
choosing the colors on each wall. they are in the following order:

1 = red
2 = blue
3 = green

The puzzle will always follow this order, so for example, if your color
was Magenta, then puzzle tile 1 (the puzzle tile on the left side) will
be red (because it's #1) and puzzle tile 2 will be blue (the next color
in line of the list. For those who don't understand, the answers are as
follows:

Magenta: Red (Left wall) + Blue (Right wall)
Cyan: Blue (Left wall) + Green (Right wall)
Yellow: Red (Left wall) + Green (Right wall)

After solving, the water will drain exposing a key, pick it up and 
another wreath will indicate a lock to be opened. Next, click on your
pocket and you will find the last key and it will indicate a lock to 
be opened with the wreath, but not so fast! If you were to stick that
key in the last lock without disabling the power first, you will be 
zapped to death. So click on the breaker box to your immediate right, 
it will open, click it again to shut off the power. Now you may proceed
to open the final lock.